1.
Amyotroph Lateral Scler
; 12(2): 144-7, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21198418
RESUMO
The objectives of this study were to investigate the presence of the three neurofilament subunits, ubiquitin, proteasome and 3-nitrotyrosine, in CSF samples of ALS patients. CSF samples were obtained by lumbar puncture from 10 ALS patients and six controls. All samples were analysed by Western blotting. Results revealed that neurofilament heavy subunit was identified in 70% of ALS cases and we conclude that this subunit may be a promising biomarker for clinical diagnosis of ALS.